![]() Silk fibroin (SF), a fibrous protein produced by silkworms Bombyx mori, thanks to its extraordinary mechanical, physical, biological, and biodegradable properties, gained great attention for biomedical applications, and it is considered a promising biomaterial for bone tissue engineering used to generate scaffolds in various formats such as hydrogels, spheres, capsules, films, and sponges. Different biomaterials, natural and synthetic, bioresorbable and permanent, have been studied for their production. Potential topics include but are not limited to applications in dentistry, odontostomatology, orthopedics, and maxillofacial surgery.įrom silk cocoons, fibroin supports for stem cells with applications in tissue engineering*, regenerative medicine and oncology.Īrticle published on – Section “Applied Biosciences and Bioengineering”: “Silk Fibroin Scaffolds as Biomaterials for 3D Mesenchymal Stromal Cells Cultures”.īiodegradable scaffolds play an important role in creating a 3D environment to induce tissue formation and, together with stem cell technologies, are believed to hold enormous potential for tissue regeneration. This Special Issue invites papers that cover original research on advances in applied biomaterials and regenerative medicine for innovative biomedical applications as well as for improving the state of knowledge related to evidence that can be applied in the design, characterization, and evaluation of critical aspects. This article, among the many published on the subject, is of particular interest for Serinnovation as the studies were carried out thanks to the supply of silk shells provided by the CREA of Padua which, for the purpose, used the cocoons produced by farmers within the project.Īdvances in Biomedical Applications: Biomaterials, Medical Devices and Regenerative Medicine. “Applied Sciences” is an international, peer-reviewed, open access journal on all aspects of applied natural sciences published semimonthly online by MDPI. The investigators hypothesize that the novel silk protein microparticle-based filler will have a favorable safety profile for use as an injectable material in the human larynx and it will produce durable clinical benefit lasting up to 12 months.Study published on the international journal “Applied Sciences”, by the Italian National Institute of Health and the University of Rome “La Sapienza” Outcome measures evaluated pre- and post-injection and over follow-up visits will include various patient reported quality of life indices, objective clinical assessments of voice, laryngeal videostroboscopy examinations, and acoustic/aerodynamic testing. Patients with unilateral vocal fold paralysis identified at the study sites will be offered participation in this study to receive injection augmentation of the paralyzed vocal fold with the filler material under investigation. Given the potential advantages of such a material, Brown et al engineered and studied a novel silk protein microparticle-based filler material suitable for injection augmentation. Surgical scaffolds derived from silk have been used for reconstructive surgery, due to its ability to allow cellular infiltration and encourage tissue regeneration/remodeling. Silk is derived from the Bombyx mori silk worm and has a long history as a surgical biomaterial. However, all of the current injection choices have individual limitations such as temporary effect, unpredictability due to variable resorption by the body, unfavorable mechanical properties, and challenging handling attributes. Various materials are used for injection augmentation including autologous fat, hyaluronic acid, collagen, carboxymethylcellulose, and calcium hydroxyapatite. Injection augmentation has many advantages including its minimally invasive nature, overall safety and low risk/complication rate, immediate clinical effect, and ability to perform it at the bedside or in-office. ![]() One manner in which this is done is via injection of a filler or bulking agent into the vocal fold in order to augment it. The presence of vocal fold paralysis with glottal insufficiency can lead to decreased quality-of-life, as well as increase risks of complications such as aspiration pneumonia.Ĭurrent treatments for vocal fold paralysis are based around techniques to medialize the paralyzed vocal fold. It often results in glottal insufficiency, which is the inability of the true vocal folds to meet and achieve complete closure during normal physiologic functions such as speech, swallowing, and coughing. Vocal fold paralysis is a clinical condition that arises commonly as a complication of surgery, endotracheal intubation, malignancy, or idiopathic etiologies. Why Should I Register and Submit Results?. ![]()
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